novel reagents for the spectrophotometric determination of isoniazid in pure and pharmaceutical formulations

Novel Reagents for the Spectrophotometric Determination of Isoniazid in Pure and Pharmaceutical Formulations

New, simple and cost effective spectrophotometric methods have been developed for the quality assessment of isoniazid (INH), in bulk and in pharmaceutical formulations by using novel reagents. The proposed methods involve the utility of ethyl 2-[(E)-(4hydroxyphenyl) diazenyl]-3-oxobutanoate and benzil as novel reagents for the determination of INH. Developed methods are based on the condensatio...

Spectrophotometric determination of isoniazid in pure and pharmaceutical formulations.

Spectrophotometric determination of etodolac in pure form and pharmaceutical formulations

BACKGROUND Etodolac (ETD) is a non-steroidal anti-inflamatory antirheumatic drug. A survey of the literature reveals that there is no method available for the determination of ETD in pure form and pharmaceutical formulations by oxidation-reduction reactions. RESULTS We describe three simple, sensitive and reproducible spectrophotometric assays (A-C) for the determination of etodolac in pure f...

Derivative Spectrophotometric Method for Determination of Losartan in Pharmaceutical Formulations

Losartan, a highly effective blood pressure lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first derivative UV spectroscopic method was developed for determination of losartan in the tablet dosage form. The first derivative spectrum r...

Spectrophotometric Determination of Tropicamide in Bulk and Pharmaceutical Formulations

     A simple and sensitive extractive spectrophotometric method is described for determination of tropicamide. The method is based on the reaction of tropicamide and bromocresol green. The ion-paired colored complex was extracted with chloroform at pH 3. The extracted complex showed maximum absorbance at 423 nm. The complex was stable up to 2 days and obeyed Beer's law over the concentration r...

Spectrophotometric Determination of Valacyclovir in Pharmaceutical Formulations

A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer’s law is obeyed in the concentration of 50-250 μg/mL of valacyclovir...